Don Quixote
In Search of Lost Time
Anna Karenina
War and Peace
The Brothers Karamazov
Crime and Punishment
Middlemarch
The Mill on the Floss
Adam Bede
A Tale of Two Cities
Bleak House
David Copperfield
Great Expectations
Ulysses
Portrait of the Artist
The Trial
Jane Eyre
Nana
Germinal
L’Assommoir
Toilers of the Sea
Notre Dame de Paris
Les Miserables
The Charterhouse of Parma
The Red and the Black
Eugenie Grandet
Cousin Bette
A Harlot High and Low
Lost Illusions
Old Goriot
Madame Bovary
Mansfield Park
Persuasion
Emma
To the Lighthouse
Mrs Dalloway
A Connecticut Yankee
Huckleberry Finn
The Scarlet Letter
Moby-Dick
Love in the Time of Cholera
Clarissa
Tristram Shandy
Tom Jones
Wuthering Heights
The Portrait of a Lady
Pale Fire
Invisible Man
Under Western Eyes
The Secret Agent
Lord Jim
Nostromo
Doctor Faustus
The Magic Mountain
Housekeeping
Gilead
The Wild Palms
Light in August
Absalom Absalom
As I Lay Dying
Disgrace
A Passage to India
Howards End
The Master and Margarita
Blood Meridian
Far from the Madding Crowd
The Return of the Native
Jude the Obscure
Women in Love
The Rainbow
Dr. Zhivago
My Struggle
The Elementary Particles
The Rebel Angels
Fifth Business
The Betrothed
Silence
Sabbath’s Theater
Operation Shylock
My Life as a Man
Portnoy’s Complaint
The Tale of Genji
Monday Begins on Saturday
Roadside Picnic
Fathers and Sons
Scoop
The Gospel According to Jesus Christ
Narcissus and Goldmund

I liked these a fair bit, but they aren’t on the same level as the above:

Things Fall Apart
Sentimental Education
The Great Gatsby
Midnight’s Children
Beloved
Song of Solomon
The Left Hand of Darkness
The Sun Also Rises
A Farewell to Arms
My Antonia
A Bend in the River
The Leopard
Invisible Cities
Orlando
Vanity Fair
The Handmaid’s Tale
Frankenstein
Lolita
Pride and Prejudice
The Pilgrim’s Progress
Lord of the Rings
The Picture of Dorian Gray
Kim
The Wind in the Willows
All the King’s Men
A Confederacy of Dunces
The Sound and the Fury
Zuckerman Bound

Some plausible candidates that I have not read:

Dream of the Red Chamber
Journey to the West
Romance of the Three Kingdoms
The Death of Virgil
The Man Without Qualities
The Golden Bowl
The Ambassadors
Pedro Páramo
Life and Fate
Our Mutual Friend
A House for Mr. Biswas
Austerlitz
The Rings of Saturn
My Brilliant Friend
Never Let Me Go
The Remains of the Day
The Age of Innocence
The House of Mirth
Buddenbrooks
The Way We Live Now
Under the Volcano
Underworld
White Noise
Oscar and Lucinda
Illywhacker
The Kelly Gang
Death Comes to the Archbishop
Jonathan Strange and Mr. Norrell
Piranesi
Kristin Lavransdatter
The Castle
Jayber Crow
Explosion in a Cathedral
The Lost Steps
The Kingdom of this World
The Savage Detectives
2666
Blindness
Stoner
Dom Casmurro
Bras Cubas
Quncas Borba
La Regenta
Fortunata and Jacinta
The Maias
The Relic
Snow Country
The Makioka Sisters
Woman in the Dunes
Kokoro
The Temple of the Golden Pavillion
The Sea of Fertility
A Personal Matter

There may be more.

Have appeared on various lists of this kind, of varying quality, but which I think implausible for the top 100, based either on my own reading or critical opinion:

Robinson Crusoe
Wolf Hall
Wide Sargasso Sea
The Blue Flower
The Moonstone
Sense and Sensibility
Dracula
Brave New World
1984
Uncle Tom’s Cabin
Dune
Brideshead Revisited
Lonesome Dove
Rebecca
Kindred
The Talented Mr. Ripley
Catch 22
Jacob’s Room
The Bluest Eye
The Color Purple
Heart of Darkness
The Grapes of Wrath
East of Eden
Cry the Beloved Country
The Golden Notebook
The End of the Affair
The Power and the Glory
Ragtime
The Prime of Miss Jean Brodie
Giovanni’s Room
Go Tell It on the Mountain
Nightmare Abbey
Gone with the Wind
Arthur Gordon Pym
Sybil
Little Women
Kidnapped
The Sign of Four
New Grub Street
Call of the Wild
Mr. Polly
Zuleika Dobson
The 39 Steps
Of Human Bondage
Babbitt
1919
Tropic of Cancer
The Big Sleep
Party Going
At Swim Two-Birds
The Heat of the Day
The Catcher in the Rye
Lord of the Flies
On the Road
Voss
To Kill a Mockingbird
A Single Man
A Clockwork Orange
Rabbit novels
Mrs. Palfrey
The Bell Jar
In Cold Blood
That Hideous Strength
Fahrenheit 451
Laurus
Peace Like a River
Wise Blood
The Moviegoer
True Grit
The Island of the World
American Pastoral
Their Eyes Were Watching God
The Count of Monte Cristo

Have appeared on some lists, but I don’t know enough about these:

Almost Spring
The Line of Beauty
The Vegetarian
The Transit of Venus
The God of Small Things
A Fine Balance
Artist of the Floating World
The Beginning of Spring
Breathing Lessons

I’ve excluded novellas.